Synthesis Of Fused Dihydrobenzo [4,5] Imidazo [1,2-a] Pyrmido [5,4-e] Pyrmidin-3 (4H)-amine Derivatives

  Some of fused dihydrobenzo [4,5]imidazo [1,2-a] pyrmido [5,4-e] pyrmidin-3(4H)-amine  derivatives were synthesized,  theses derivatives derived from 4-amino-2-(4-chloro or bromophenyl) -1,2-dihydropyrimido[1,2-a] benzimidazole-3-carbonitrile (4,5), which prepared by reaction 1H-benzimidazol-2-amine (1) and p-chlorobenzaldehyde p-bromobenzaldehyde (2)  and malononitrile (3). These compound (4,5) with triethylorthoformate in presence acetic anhydride to give the products (6,7), then was reacted aliphatic amines (hydrazine, methyl amine, ethyl propyl amine isobutyl amine) pyrmidin rings (8-17) respectively. All these characterization FT-IR , HNMR spectra physical properties.